11-Dioxy-cis-4,5-didehydro-PGF compounds

ABSTRACT

This invention relates to a group of cis-4,5-didehydro-11-deoxy-PG 1  analogs having variable chain length, optional methyl substitution in the methyl-terminated side-chain, and processes for making them. These compounds are useful for a variety of pharmacological purposes, including ulcer treatment, inhibition of platelet aggregation, increase of nasal patency, and labor induction at term.

This application is a division of Ser. No. 548,586, filed Feb. 10, 1975, now issued as U.S. Pat. No. 3,987,072.

The present invention relates to prostaglandin analogs, for which the essential material constituting a disclosure thereof is incorporated by reference here from U.S. Pat. No. 3,987,072, issued Oct. 19, 1976. 

We claim:
 1. A compound of the formula ##STR1## or a mixture comprising that compound and the enantiomer thereof; WHEREIN R₁ is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive, or a pharmacologically acceptable cation.
 2. A compound of the formula ##STR2## or a mixture comprising that compound and the enantiomer thereof; WHEREIN R₁ is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive, or a pharmacologically acceptable cation.
 3. A compound of the formula ##STR3## or a mixture comprising that compound and the enantiomer thereof; WHEREIN R₁ is hydrogen, alkyl of one to 12 carbon atoms, inclusive, cycloalkyl of 3 to 10 carbon atoms, inclusive, aralkyl of 7 to 12 carbon atoms, inclusive, phenyl, phenyl substituted with one, 2, or 3 chloro or alkyl of one to 4 carbon atoms, inclusive, or a pharmacologically acceptable cation.
 4. cis-4,5-Didehydro-11-deoxy-16,16-dimethyl-PGF₁α, 15-methyl ether, methyl ester, a compound according to claim
 3. 